Doctor of Philosophy, Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio
Bachelor of Science, Biology with a specialization in Molecular Biology, Texas Lutheran University, Seguin, Texas
Laboratory consulting on performing stroma cultures, analysis of stroma function, and stroma data analysis, June 2013
Dr. Perez is interested in the fundamental problems of how the bone marrow microenvironment participates in the development of myelodysplastic syndrome (MDS). Primarily a disease of the elderly, MDS can also develop after benzene exposure. As the elderly population in Texas increases and exposure to benzene rises because of emerging petroleum industries across south Texas, so will the need for understanding how the bone marrow microenvironment participates in the development of MDS. Current research in Dr. Perez’s lab focuses on the effects of benzene metabolites on bone marrow stromal cell lines.
Zimmer SN, Lemieux ME, Karia BP, Day C, Zhou T, Zhou Q, Kung AL, Suresh U, Chen Y, Kinney MC, Bishop AJ, and Rebel VI. Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm. Experimental Hematology. 2012, 40:295-306. (PMID: 22198154)
Zimmer SN, Zhou Q, Zhou T, Cheng Z, Abboud-Werner SL, Horn D, Lecocke M, White R, Krivstov AV, Armstrong SA, Kung AL, Livingston DM and Rebel VI. Crebbp haploinsufficiency alters the bone marrow microenvironment leading to excessive myelopoiesis and stem cell loss. Blood. 2011, 118:69-79. (PMID: 21555743)
Harris SE, MacDougall M, Horn D, Woodruff K, Zimmer SN, Rebel VI, Fajardo R, Feng JQ, Gluhak-Heinrich J, Harris MA, and Abboud Werner S. Meox2Cre-mediated disruption of CSF-1 leads to osteopetrosis and osteocyte defects. Bone. 2012, 50:42-53. (PMID: 21958845)
(All as Stephanie N. Zimmer)